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Nonsense-mediated decay - Wikipedia
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain …
Mechanism and regulation of the nonsense-mediated decay pathway
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular …
Nonsense-mediated mRNA decay (NMD) mechanisms - Nature
Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs).
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Nonsense-mediated mRNA decay: Physiological ... - ScienceDirect
Dec 1, 2024 · It is crucial to comprehend the long-term effects and potential risks associated with therapeutic modulation of NMD. In this review, we briefly discuss NMD’s mechanism of action and …
The NMD Pathway: Function in Health and Disease
Jun 18, 2025 · The primary function of the NMD pathway is to protect the cell from producing shortened, or truncated, proteins. These incomplete proteins often lack the ability to perform their intended jobs …
Composite SMG5-SMG6 PIN domain formation is essential for NMD
1 day ago · Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with …
Nonsense-mediated mRNA decay, a simplified view of a complex …
Nonsense-mediated mRNA decay (NMD) is both a quality control mechanism and a gene regulation pathway. It has been studied for more than 30 years, with an accumulation of many mechanistic …
Nonsense-Mediated mRNA Decay: Pathologies and the Potential for …
Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a surveillance pathway used by cells to control the quality mRNAs and to fine-tune transcript abundance. NMD plays an important role in cell …