An expert from the FDA explained the benefits and limitations of these two clinical trial formats and how the cancer field can learn from both. The use of single-arm trials, in which all patients ...

Intensive care unit (ICU)–acquired weakness often develops in patients who are undergoing invasive mechanical ventilation. Early active mobilization may mitigate ICU-acquired weakness, increase ...

Patient-reported outcome measures and clinical scales were ineffective in predicting responses to full-agonist opioids for chronic pain.

Research indicates that many statin therapy side effects are not supported by evidence, suggesting a need for revised ...

We are witnessing an increasing demand for rapid, rigorous, and generalizable evidence to inform health care systems’ learning and address inefficiencies in the current clinical trials landscape.