The aim of this paper is to provide an overview of sample size estimations for the most frequent type of group studies that result in continuous, binary and ordered categorical outcomes. In recent ...

Power analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required sample size for ...

Beyond the design, if enrollment slows due to seasonal effects or difficulty finding a niche patient group, a robust design activates a contingency plan that dynamically adjusts site selection based ...

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...

In the first part of this piece I pointed out why it can be difficult to validate TAR using control set metrics. When the overall proportion of responsive documents is very low, it becomes ...