As humans and other animals navigate their surroundings and experience different things, their brain creates so-called cognitive maps, which are internal representations of environments or tasks.

Overexpression of Shisa7 in the orbitofrontal cortex in drug-free rats induced comparable up and down changes in gene expression as that induced by the self-administration of heroin. The concordant ...

Neuronal pathways originating from the orbitofrontal cortex (OFC) of the brain participate in different adaptive behaviors, but which pathways are used for distinct adaptive strategies remains unclear ...

Depression imposes a major global socioeconomic burden, and current pharmacotherapies face several limitations, including slow efficacy, adverse effects, and non-response rates of up to 55%, ...

Study reveals how aging accelerates molecular changes in the brain, offering new hope for tackling cognitive decline and mental illness. Resource: Single-nucleus transcriptomic profiling of human ...

Now, scientists from the University of Warwick have made important progress in learning what causes alcohol addiction in the ...