During the process of metastasis, tumor cells inevitably encounter the stimulation of various oxidative stressors, resulting in the fluctuation of intracellular reactive oxygen species (ROS) levels.

Diffuse midline glioma (DMG), H3K27-altered, is a lethal pediatric high-grade tumor, lacking effective treatment options, primarily depending on clinical trials. Epigenetic agent-based immunotherapy ...

In the cancer type multiple myeloma, the malignant cells differ significantly from normal cells regarding the layer of chemical "tags" on DNA and proteins that control whether genes are turned on or ...

Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the ...

Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...

Resistant cells demonstrated global decreases in DNA accessibility with localized opening at resistance-driving loci, ...

Shedding light on what determines how cells become what they are meant to be-nerves, bone, muscles, etc.-can also help researchers understand how diseases develop when these biological programs break ...

Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have shown for the first time that, before they can start developing into egg and sperm cells, the embryonic ...

Morphoceuticals is a biotechnology company that surveys the body’s nonneural bioelectric signaling networks. These networks, which enable disparate cells to serve collective purposes, constitute the ...