A distinct signaling pathway called TNF- drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF- program and become invasive ...

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer. While indispensable for embryonic patterning ...

Even before a tumor in the pancreas becomes discernible, an activated cancer gene actively remodels its future environment ...

Notoriously tricky to detect, pancreatic cancer also often resists traditional therapy. So, researchers are urgently looking for new ways to disrupt tumor formation. Though scientists know that the ...

A new editorial was published in Oncotarget, Volume 16, on March 10, 2025, titled "EXPOSOMES and GENES: The duo influencing CANCER initiation and progression." In this editorial, Drs. Uzma Saqib, ...

Researchers at Åbo Akademi University have identified a new molecular change in patients with colorectal cancer and developed a genetic disease model that forms tumors in the large intestine, ...